Rhiannon Fish and Lincoln Younes have both been tipped to leave the soap.
Fish, who plays April Scott, has hinted at plans to depart the long-running show in favour of new acting projects.
The 22-year-old told TV Week: "I've got something that is in the works in Australia, but then I'm heading over to Los Angeles next year. It's exciting and I want to do something that makes me nervous and puts me on my toes again.
"I'm just so happy to have had this experience and now be going on to something different."
On saying goodbye to the Home and Away team, she added: "They become your family, so it will be very sad."
Fish today (April 15) followed up her interview by tweeting that she has no plans to leave "anytime soon". However, departing Home and Away cast members often deny reports of their exits to keep fans guessing.